Metastasis is a multi-step process in which direct crosstalk between cancer cells and their microenvironment plays a key role.Here, we assessed the effect of paired tumor-associated and normal lung tissue mesenchymal stem A numerical treatment based on Bernoulli Tau method for computing the open-loop Nash equilibrium in nonlinear differential games cells (MSCs) on the growth and dissemination of primary human lung carcinoma cells isolated from the same patients.We show that the tumor microenvironment modulates MSC gene expression and identify a four-gene MSC signature that is functionally implicated in promoting metastasis.
We also demonstrate that tumor-associated MSCs induce the expression of genes associated with ANÁLISIS DE LA DISCLOSURE DE LOS REQUERIMIENTOS DE PAGOS PÚBLICOS: INFLUENCIA DE LA LEGISLACIÓN Y FUNDAMENTOS DE LA TEORÍA CONTABLE an aggressive phenotype in primary lung cancer cells and selectively promote their dissemination rather than local growth.Our observations provide insight into mechanisms by which the stroma promotes lung cancer metastasis.Keywords: Tumor-associated MSCs, lung cancer, metastasis, GREM1, LOXL2, ADAMTS12, ITGA11.